The crash occurred at about 12:40 p.m. in White County on I-65.
Piers said that multiple injuries were reported from the Greyhound bus from passengers, as well as the driver, but none of them are life-threatening at this time.
According to Piers, it is believed the SUV was clipped by another vehicle and then lost control, careened across the median and into the bus.
Greyhound said in a statement that the bus originated in Louisville, Kentucky, with Chicago as a final destination.
It added: “Our thoughts and prayers are with everyone involved in today’s incident. Our priority is taking care of all the passengers, employees and families affected and we will continue to support local authorities with this matter. We can confirm the Greyhound driver and several passengers have been transported to area hospitals.”
This is a developing story and will be updated.