Christina Applegate admits she is grappling with ‘real, f**t it all’ depression as she copes with multiple sclerosis battle

Christina Applegate candidly described the mental anguish she had been feeling amid her battle with multiple sclerosis, admitting she had been in a ‘real’ depression as she copes with her chronic condition.

On the podcast she shares with friend Jamie Lynn-Sigler, MeSsy, Christina admitted she has been in a ‘real, f**k it all’ depression that has begun to scare her.

The episode – which was recorded in early 2024 – also saw Christina, 52, reflect on her appearance at the Emmys, which she described as the most challenging day of her life.

‘This is being really honest…I don’t enjoy living. I don’t enjoy it. I don’t enjoy things anymore,’ she admitted.

‘If someone can come over and lay in bed with me and talk, like you have and like a girlfriend of mine did the other day… that’s enjoyable. I enjoy that,’ Christina added. ‘But if someone’s like, “let’s get up and go for a walk” or “let’s go get a coffee”, I’m like, I don’t enjoy that process.’ 

Jamie, 43, who also suffers from multiple sclerosis, advised her friend to avoid comparing her current state to her past: ‘It’s so hard to live in a disabled body. It is so hard. I will not take that away from you and I am right there with you,’ she said.

‘But what makes it harder is when you compare it to how it used to be. I mean I still do it all the time, but in the moments where I have just a little more acceptance.. it takes a little bit of the suffering out of it,’ she continued.

‘Once we get you to this place where we’re accepting that this is how it’s going to be, maybe forever… to me it’s not a reason enough for you to stop living because I sit here across from you and you still make me laugh like nobody else can. 

‘You still make me smile. You still make me feel loved.

‘I can’t let you give up. I can’t do it. I need you to do it for me,’ she added. ‘I’m hoping that this podcast will also show you even more of your value and show you yourself how incredibly strong you are and how much you deserve to give yourself a chance,’ Sigler said.

Christina went on to describe the state of her mental health, revealing: ‘I’m in a depression right now, which I don’t think I’ve felt that for years. Like a real, f**k it all depression. 

‘Like, real depression, where it’s kind of scaring me too a little bit because it feels really fatalistic. It feels really “end of”, you know not saying that, I don’t mean that, I just mean like I’m trapped in like this darkness right now that I haven’t felt like that in I don’t even know how long, probably 20 something years.’

She also called her appearance at the Emmy Awards ‘the hardest day of my life’ and admitted she slept for ‘two days’ following the event.

But Christina is seeking support – she contacted a therapist who she planned on seeing soon.

However, she had long avoided therapy in an attempt to prevent facing the emotions: ‘I have avoided therapy since I’ve been diagnosed because I’m so afraid to start crying and that I’m not going to be able to end crying.’

‘I just am so I’m so afraid for those floodgates to open and that I won’t be able to stop,’ she added. 

But Jamie urged her to truly feel her emotions: ‘I feel like you owe it to yourself to cry and really, really go there….You gotta allow yourself to feel that stuff. You can’t keep pushing it away, otherwise you’re gonna be where you’re at right now. You’re like in a purgatory, you know?’

Christina was diagnosed with MS in 2021 while Jamie received her diagnosis at age 20.

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